Acid reflux occurs when stomach acid flows back into the esophagus, causing discomfort and symptoms like heartburn, a sour taste, and throat irritation. While occasional reflux is normal and usually goes away on its own or can be treated by an over-the-counter (OTC) antacid, ongoing symptoms may lead you to look for other remedies.
Besides prescription and OTC medications, some people find relief from dietary supplements to ease symptoms. However, it’s important to remember that dietary supplements are not a cure and should be used alongside healthy diet and other healthy habits for the best results.
1. Probiotics
Probiotics are live microorganisms, such as bacteria and yeast, that are commonly found in fermented foods like yogurt and kimchi. Available as supplements, probiotics are often used to support gut health, but some studies suggest they may also help reduce acid reflux symptoms.
Probiotics may alleviate acid reflux by affecting immune function and protecting the stomach lining from acid. Probiotics may also decrease acid production and aid digestion.
A review of 13 studies looked at various probiotic strains and their impact on acid reflux symptoms. Results were mixed, but overall, 79% of studies reported some benefit in reducing symptoms like heartburn, dyspepsia (indigestion), gas, and stomach pain.
One study focused on probiotics containing Lactobacillus johnsonii found significant improvements in heartburn and indigestion after six weeks of use, compared to placebo (an ineffective substance give to participants in clinical trial control groups).
It’s possible that taking probiotic supplements could improve acid reflux symptoms. But they may not work for everyone, based on the mixed results seen in studies. Though probiotics are generally well tolerated, some people have mild side effects, such as bloating or flatulence.
2. Iberogast
Iberogast is a proprietary supplement product. Also known as STW 5-II, Iberogast comes in soft gels and liquid drops and contains a six-plant blend of herb extracts, including:
Iberogast is mainly used to manage occasional stomach upset and irritable bowel syndrome (IBS), a condition affecting the gastrointestinal (GI) system. However, it may also help with heartburn and acid reflux symptoms by regulating GI movement and the production of digestive juices.
In one study, Iberogast significantly reduced reflux symptoms within 30 to 60 minutes of administration, and 40% of participants were symptom-free after a few days of use. However, a separate study comparing Iberogast to placebo showed no significant difference in heartburn relief.
A 2024 meta-analysis involving 613 people found that Iberogast improved various symptoms of functional dyspepsia (persistent indigestion with no clear cause), including heartburn, after 28 days of use.
Side effects are typically mild but may include headache and loss of appetite. Note that Iberogast contains alcohol and is not safe for use in children, pregnant people, or people who have certain medical conditions.
3. FDgard
FDgard is a supplement that supports digestive health and provides short-term indigestion relief. It contains caraway oil and L-menthol. FDgard is thought to work by relaxing the intestines, potentially reducing pain and inflammation, and helping protect the stomach lining.
While some research shows positive benefits with FDgard, others suggest that there is little difference from placebo. Some studies show that FDgard may alleviate symptoms of functional dyspepsia, such as pressure and fullness after meals, as well as upper abdominal pain.
A 2022 study of 600 people found FDgard helped reduce symptoms of functional dyspepsia in 95% of participants. Most people reported rapid symptom relief within two hours of taking the supplement. No serious side effects were reported with long-term use.
While these studies show that FDgard may offer relief for indigestion, its effects on heartburn and acid reflux are unclear.
4. Melatonin
Melatonin, a hormone produced naturally by the body, is mainly known for its ability to regulate sleep cycles. However, melatonin also plays a role in regulating stomach acid and protecting the stomach lining, making it a possible supplement for acid reflux relief.
Research suggests melatonin, particularly when combined with omeprazole—the active ingredient in Prilosec, a medication for acid reflux— can reduce symptoms like heartburn and upper abdominal pain. One study showed that melatonin alone also improved symptoms after four weeks, with participants reporting more improvement in their daily lives than those taking a placebo.
Melatonin is generally safe but can cause side effects like drowsiness, nausea, and dizziness. So, it’s important to avoid driving after taking melatonin.
5. B Vitamins
Vitamin B deficiencies are associated with acid reflux and treatment with proton pump inhibitors (PPIs). This usually happens when PPIs are taken for a long time, leading to decreased absorption of vitamin B12.
Research on B vitamins and their association with acid reflux is conflicting. Generally, studies found lower vitamin B12 in people taking long-term PPIs than in those not taking them.
While the evidence is mixed, some studies suggest that B vitamins, including folic acid (B9) and pyridoxine (B6), may help reduce acid reflux symptoms like heartburn and chest pain.
However, due to a lack of reliable studies and conflicting results, B vitamins are not typically recommended for acid reflux unless there’s a documented deficiency. If you’re taking a long-term PPI medication, ask your healthcare provider if you could benefit from vitamin B supplements.
6. Ginger
Ginger is well-known for its natural anti-nausea properties, but it may also relieve symptoms of acid reflux. It’s believed to reduce reflux by helping food move more quickly through the digestive tract.
Ginger has proven effective for pregnancy-related nausea (morning sickness) and motion sickness, but limited evidence supports its role in helping with acid reflux. Other studies suggest ginger improves indigestion symptoms, such as belching and feeling full.
While ginger can help with nausea, it may not address other reflux symptoms like heartburn or chest discomfort. Ginger might help if your acid reflux symptoms are related to nausea or vomiting.
Side Effects & Precautions of Acid Reflux Supplements
While many dietary supplements are generally safe for most adults, some can cause mild gastrointestinal side effects like nausea, bloating, and diarrhea.
Additionally, some supplements may interact with medications. For example, ginger can increase the risk of bleeding when taken with blood thinners like Jantoven (warfarin). Always consult your healthcare provider before starting any new supplement to avoid potential interactions and ensure it is safe for your specific health needs.
It’s also a good idea to check with a healthcare provider before using acid reflux supplements during pregnancy, while breastfeeding, or for children. As mentioned, some supplements, such as Iberogast, contain alcohol and may not be suitable for some people.
A healthcare professional can discuss the best supplements for acid reflux for you or recommend other treatment options available over the counter or by prescription.
Lifestyle Changes to Support Acid Reflux Relief
Making lifestyle changes can significantly improve acid reflux symptoms. Here are a few tips to support your digestive health:
- Watch your diet: Avoid spicy, high-fat, and acidic foods. Smaller meals may help too.
- Avoid alcohol and smoking: These substances can trigger or worsen reflux.
- Stay upright after eating: Wait two to three hours before lying down after eating meals.
- Elevate the head of your bed: Sleeping with your head raised uses gravity to help keep acid down.
- Weight loss: If you’re overweight, losing a weight can reduce symptoms.
When to See a Provider
If your acid reflux symptoms persist despite OTC treatments and lifestyle changes, or if your symptoms feel severe, it’s time to see a healthcare provider. Frequent heartburn symptoms (more than twice a week) may be treated with acid-reducing medications.
Seek medical attention immediately if you experience:
- Difficulty swallowing
- Intense pain
- Trouble breathing
- Vomiting blood
The Food and Drug Administration (FDA) does not regulate dietary supplements the way it does for prescription medications. As a result, some supplement products may not contain the ingredients listed on the label.
When choosing a supplement, look for products independently tested or certified by organizations such as NSF, U.S. Pharmacopeiaor ConsumerLab.com. For personalized guidance, consult your healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
Summary
Acid reflux can be uncomfortable, but various dietary supplements are available without a prescription that may help manage symptoms. Examples include probiotics, Iberogast, FDgard, melatonin, B vitamins, and ginger. However, dietary supplements are not meant to treat or cure any underlying disease and should be used in addition to lifestyle changes for optimal benefit.
Individual results may vary. Always consult a healthcare professional before starting any new supplement to ensure it is right for you and will not interfere with other treatments.
